The new report "Wrestling with social and behavioral genomics" has good points, but risks being interpreted so as to bias scientific research. In response, I propose a Principle of Symmetry.
How does PGI scoring for educational attainment compare with the predictive power of environmental variables such as parental income, childhood zip code, etc.?
Better than some, worse than some! But note that many of those variables will correlate with, and be plausibly caused by, parental polygenic scores, including the unmeasured part of parental polygenic scores (which in turn correlate with the unmeasured part of your own polygenic score). That may matter, depending on what you want to do - e.g. if you want to estimate "how much genetics matters" or if you just want to use PGS/zip code/etc as a useful predictor.
Great essay, thank you
Man all this work and so few comments!
This entire piece is very well said. I'll be thinking about it for quite a while. Thanks.
Do share it :-)
How does PGI scoring for educational attainment compare with the predictive power of environmental variables such as parental income, childhood zip code, etc.?
Better than some, worse than some! But note that many of those variables will correlate with, and be plausibly caused by, parental polygenic scores, including the unmeasured part of parental polygenic scores (which in turn correlate with the unmeasured part of your own polygenic score). That may matter, depending on what you want to do - e.g. if you want to estimate "how much genetics matters" or if you just want to use PGS/zip code/etc as a useful predictor.
“woke opposition” is increasingly people calling out toxically contrarian behaviors uninterested and unable to learn 🤔